Select Publications
In situ cell-surface conformation of the TCR-CD3 signaling complex
Natarajan, Aswin; Velmurugu, Yogambigai; Becerra Flores, Manuel; Dibba, Fatoumatta; Beesam, Saikiran; Kikvadze, Sally; Wang, Xiaotian; Wang, Wenjuan; Li, Tianqi; Shin, Hye Won; Cardozo, Timothy; Krogsgaard, Michelle
EMBO reports. 2024 November 7. doi.org/10.1038/s44319-024-00314-3
Phosphopeptide Neoantigens as Emerging Targets in Cancer Immunotherapy
Tyagi, Apoorvi; Patskovsky, Yury; Voloshyna, Iryna; Krogsgaard Michelle
Journal of Cancer Immunology. 2024 September 26; 6(4):135-147.
Longitudinal study of immunity to SARS-CoV2 in ocrelizumab-treated MS patients up to 2 years after COVID-19 vaccination
Ilya Kister, Ryan Curtin, Amanda L. Piquet , Tyler Borko, Jinglan Pei, Barbara L Banbury, Tamar E. Bacon, Angie Kim, Michael Tuen, Yogambigai Velmurugu, Samantha Nyovanie, Sean Selva, Marie I. Samanovic, Mark J. Mulligan, Yury Patskovsky, Jessica Priest, Mark Cabatingan, Ryan C. Winger, Michelle Krogsgaard, Gregg J. Silverman
Annals of Clinical and Translational Neurology 2024 May 7; https://doi.org/10.1002/acn3.52081
Structural Basis for Self-Discrimination by Neoantigen-Specific TCRs
John P. Finnigan, Jenna H. Newman, Yury Patskovsky, Larysa Patskovska, Andrew S. Ishizuka, Geoffrey M. Lynn, Robert A. Seder,
Michelle Krogsgaard, Nina Bhardwaj
Nature Communications 15, 2140 2024 March 8; https://doi.org/10.1038/s41467-024-46367-9
Molecular mechanism of phosphopeptide neoantigen immunogenicity
Yury Patskovsky, Aswin Natarajan, Larysa Patskovska, Samantha Nyovanie, Bishnu Joshi, Benjamin Morin, Christine Brittsan, Olivia Huber, Samuel Gordon, Xavier Michelet, Florian Schmitzberger, Robert B. Stein, Mark A. Findeis, Andy Hurwitz, Marc Van Dijk, Jennifer S. Buell, Dennis Underwood, Michelle Krogsgaard
Nature Communications 14, 3763 2023 June 23; https://doi.org/10.1038/s41467-023-39425-1
Catch bond models may explain how force amplifies TCR signaling and antigen discrimination
Hyun-Kyu Choi, Peiwen Cong, Chenghao Ge, Aswin Natarajan, Baoyu Liu, Yong Zhang, Kaitao Li, Muaz Nik Rushdi, Wei Chen, Jizhong Lou, Michelle Krogsgaard, Cheng Zhu
Nature Communications 14, 2616 2023 May 5; https://doi.org/10.1038/s41467-023-38267-1
Hybrid and vaccine-induced immunity against SARS-CoV-2 in MS patients on different disease-modifying therapies
Ilya Kister, Ryan Curtin, Jinglan Pei, Katherine Perdomo, Tamar E. Bacon, Iryna Voloshyna, Joseph Kim, Ethan Tardio, Yogambigai Velmurugu, Samantha Nyovanie, Andrea Valeria Calderon, Fatoumatta Dibba, Stanzin Idga, Marie I. Samanovic, Pranil Raut, Catarina Raposo, Jessica Priest, Mark Cabatingan, Ryan C. Winger, Mark J. Mulligan, Yury Patskovsky, Gregg J. Silverman, Michelle Krogsgaard
Annals of Clinical and Translational Neurology 2022 September 27; doi.org/10.1002/acn3.51664
Baseline Serum Autoantibody Signatures Predict Recurrence and Toxicity in Melanoma Patients Receiving Adjuvant Immune Checkpoint Blockade
Paul Johannet, Wenke Liu, David Fenyo, Megan Wind-Rotolo, Michelle Krogsgaard, Janice M. Mehnert, Jeffrey S. Weber, Judy Zhong, Iman Osman
Clinical Cancer Research : an official journal of the American Association for Cancer Research, 2022 September 15; 28(18), 4121–4130
Cooperative ectodomain interaction among TCRαβ, CD3γε, and CD3δε enhances TCR mechanotransduction
Zhou Yuan, Peiwen Cong, Aswin Natarajan, Chenghao Ge, Stefano Travaglino, Saikiran Beesam, Danielle Grazette, Michelle Krogsgaard, Cheng Zhu
bioRxiv 2022.04.14.488403; doi: https://doi.org/10.1101/2022.04.14.488403
Cellular and humoral immunity to SARS-CoV-2 infection in multiple sclerosis patients on ocrelizumab and other disease-modifying therapies: a multi-ethnic observational study
Ilya Kister, Yury Patskovsky, Ryan Curtin, Jinglan Pei, Katherine Perdomo, Zoe Rimler, Iryna Voloshnya, Marie I Samanovic, Amber R Cornelius, Yogambigai Velmurugu, Samantha Nyovanie, Joseph Kim, Ethan Tardio, Tamar E Bacon, Lana Zhovtis Ryerson, Pranil Raut, Rosetta Pedotti, Kathleen Hawker, Catarina Raposo, Jessica Priest, Mark Cabatingan, Ryan C Winger, Mark J Mulligan, Michelle Krogsgaard, Gregg J Silverman
Annals of Neurology 2022 Mar 15; doi: 10.1002/ana.26346
Preexisting immune-mediated inflammatory disease is associated with improved survival and increased toxicity in melanoma patients who receive immune checkpoint inhibitors
Nicholas Gulati, Arda Celen, Paul Johannet, Janice M. Mehnert, Jeffrey Weber, Michelle Krogsgaard, Iman Osman, Judy Zhong
Cancer Medicine 2021 October 14;10: 7457– 7465. doi.org/10.1002/cam4.4239
Baseline antibody profiles predict toxicity in melanoma patients treated with immune checkpoint inhibitors.
Gowen MF, Giles KM, Simpson D, Tchack J, Zhou H, Moran U, Dawood Z, Pavlick AC, Hu S, Wilson MA, Zhong H, Kirchhoff T, Krogsgaard M, Osman I.
Journal of Translational Medicine 2018 Apr 2;16(1):82. doi: 10.1186/s12967-018-1452-4.
Constitutive Lck Activity Drives Sensitivity Differences Between CD8+ Memory T Cell Subsets.
Moogk, Duane; Zhong, Shi; Yu, Zhiya; Liadi, Ivan; Rittase, William; Fang, Victoria; Dougherty, Janna; Perez-Garcia, Arianne; Osman, Iman; Zhu, Cheng; Varadarajan, Navin; Restifo, Nicholas P; Frey, Alan B; Krogsgaard, Michelle
Journal Of Immunology (1950). 2016 07 15; 197(2):644-54
Structural Model Of The Extracellular Assembly Of The TCR-CD3 Complex.
Natarajan, Aswin; Nadarajah, Vidushan; Felsovalyi, Klara; Wang, Wenjuan; Jeyachandran, Vivian R; Wasson, Riley A; Cardozo, Timothy; Bracken, Clay; Krogsgaard, Michelle
Cell Reports. 2016 Mar 29; 14(12):2833-45
Specific Increase In Potency Via Structure-Based Design Of A TCR.
Malecek, Karolina; Grigoryan, Arsen; Zhong, Shi; Gu, Wei Jun; Johnson, Laura A; Rosenberg, Steven A; Cardozo, Timothy; Krogsgaard, Michelle
Journal Of Immunology (1950). 2014 Sep 01; 193(5):2587-99CD004345
2D TCR-PMHC-CD8 Kinetics Determines T-Cell Responses In A Self-Antigen-Specific TCR System
Liu, Baoyu; Zhong, Shi; Malecek, Karolina; Johnson, Laura A; Rosenberg, Steven A; Zhu, Cheng; Krogsgaard, Michelle
European Journal Of Immunology. 2014 Jan; 44(1):239-50
Strength Of PD-1 Signaling Differentially Affects T-Cell Effector Functions.
Wei, Fang; Zhong, Shi; Ma, Zhengyu; Kong, Hong; Medvec, Andrew; Ahmed, Rafi; Freeman, Gordon J; Krogsgaard, Michelle; Riley, James L
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS). 2013 Jul 02; 110(27):E2480-9